Holy Family Parish was officially established with the groundbreaking ceremony for the church on February 11, 1950. On November 14, 1950, Archbishop Hurley of the Diocese of Saint Augustine officially named the parish The Church of the Holy Family, and Monsignor Rowan Rastatter was appointed as its first pastor.

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The groundbreaking ceremony for Holy Family Catholic School took place on January 7, 1951, and the school welcomed its first students in September 1951. Under the leadership of the Benedictine Sisters of the Holy Name Convent, Holy Family opened with an enrollment of approximately 300 students in kindergarten through sixth grade. Sister Mary Grace served as the school's first principal.

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She was succeeded by Sister Caroline (1952–1958), who oversaw Holy Family's first graduating class in 1956. She was followed by Sister Irma (1958–1960), Sister Celine (1960–1964), and Sister Rosanna (1964–1968).

Following Sister Rosanna's untimely passing in 1968, Mrs. Ruth Barbick was appointed principal, becoming the first lay principal in the Archdiocese of Miami. Holy Family was also among the first schools in the Archdiocese to employ both religious and lay faculty. Under Mrs. Barbick's leadership, the school became one of eight pilot schools in the Archdiocese of Miami to earn accreditation, marking another significant milestone in Holy Family's history.

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Since its founding, Holy Family Catholic School has remained committed to providing an exceptional Catholic education rooted in faith, academic excellence, and service. Building upon the vision of its founders, the school continues to form students who are prepared to lead with integrity, compassion, and a commitment to making a positive impact on their communities.